Lebrun Labs LLC develops and validates new approach methodologies (NAMs) for chemical safety testing. The OptiSafe eye irritation test (IVD EIT, OECD TG 496 listed, NIH/NIEHS funded: R43ES025501, R44ES025501, R44ES031881, SB1 ES025501, SB1 ES038803) classifies GHS ocular hazard categories without animal tissue or cell culture. The DermaSafe SCT skin corrosion test (NIH/NIEHS SBIR R44ES036065) classifies GHS skin corrosion categories and DOT packing groups using an in chemico, cell-free spectrophotometric method. Both methods are supported by eight peer-reviewed publications in Toxicology In Vitro and Cutaneous and Ocular Toxicology, five U.S. patents, and 11 NIH grants awarded since 2015.